Vagifem (estradiol hemihydrate)

Vagifem is a prescription medication used for hormone replacement therapy, specifically formulated as a vaginal tablet for postmenopausal symptoms. It was originally developed and manufactured by the Danish pharmaceutical giant Novo Nordisk. The product remains a staple in women's health markets globally.

While Novo Nordisk is the primary manufacturer and the historical owner of the brand, in several international markets, including Brazil (indicated by the Portuguese text on the packaging), the marketing and distribution rights are held through partnerships or licenses. The logo for Besins Healthcare on the box indicates their role as the current local license holder or distributor for this specific region. However, the intellectual property and primary global standing of the Vagifem brand are rooted in Denmark.