E45 Itch Relief Gel

E45 is a renowned skincare brand with a heritage deeply rooted in British dermatology. Originally created in 1952 by Crookes Healthcare, a subsidiary of Boots, the brand was initially designed for hospital use as a cream to soothe irritated skin. Over the decades, it transitioned into a leading consumer brand focused on medical-grade solutions for dry and sensitive skin conditions.

The manufacturing of E45 products occurs in multiple locations across Europe and Asia to support its global distribution network. In 2022, the brand underwent a significant ownership change when it was acquired from Reckitt Benckiser by Karo Healthcare. This move positioned E45 within a specialized portfolio of European consumer healthcare brands, maintaining its commitment to fragrance-free and dermatologically tested formulations.