Cymbalta (Duloxetine)

Duloxetine is a medication widely known by the brand name Cymbalta, which was originally developed and patented by Eli Lilly and Company. Research into the compound began in the late 1980s by Eli Lilly scientists in the United States, and the drug received FDA approval for the treatment of major depressive disorder in 2004. Historically, its primary manufacturing hub was located in Indianapolis, Indiana, though production expanded globally as the medication became a leading treatment for various conditions, including generalized anxiety disorder and fibromyalgia.

Following the expiration of the original patent in late 2013, the market for duloxetine shifted significantly. While Eli Lilly continues to produce the brand-name version, numerous other pharmaceutical companies—including major generic manufacturers like Teva, Aurobindo, Sun Pharma, and Lupin—now produce generic versions of the drug. Consequently, manufacturing today takes place in multiple countries including the United States, India, and Ireland, depending on the specific manufacturer and target market. Eli Lilly remains the ultimate owner of the Cymbalta brand name, maintaining its position as a global pharmaceutical leader headquartered in Indianapolis.