Trazodone

Trazodone is a prominent antidepressant medication primarily used to treat major depressive disorder, anxiety, and insomnia. It belongs to the phenylpiperazine class and functions as a serotonin antagonist and reuptake inhibitor (SARI). Originally discovered and developed in the 1960s by Angelini Research Laboratories in Italy, it was first approved for medical use in the United States in 1981 under the brand name Desyrel.

Today, Trazodone is widely available as a generic drug, produced by numerous pharmaceutical companies globally. Key manufacturing hubs for both the active pharmaceutical ingredient (API) and finished dosage forms include India, Italy, the United States, Canada, and various European nations. Major global manufacturers include Angelini Pharma, Teva Pharmaceuticals, Sandoz (a subsidiary of Sandoz Group AG), and Viatris (formerly Mylan). Ownership of the drug varies significantly by region, as it is marketed under dozens of different brand names—such as Trittico, Molipaxin, and Desyrel—by local and multinational pharmaceutical entities.